By Stanley T. Crooke,Archie W. Prestayko
Part I is a basic evaluate of anti-cancer medicinal drugs as regards their motion mechanisms, pharmacokinetics, pharmacology, recognized toxicities, and scientific application. those medicinal drugs comprise alkylating brokers akin to mitomycin C and nitrosoureas; plant alkaloids resembling maytansine; antibiotics comparable to anthracyclines; platinum-containing complexes; antimetabolites; and hormones. half II examines the molecular pharmacology of a few significant drug periods, specifically, bleomycin and anthracycline. The textual content additionally discusses the chemistry, mechanism, and any structure-activity relationships present in those drug periods. half III discusses intimately the medical pharmacology of a few antitumor medicinal drugs, for instance, cisplatin and nitrosoureas. The textual content contains the scientific functions, biochemistry, metabolism, and using mathematical versions in analyzing or describing ensuing info.
The booklet is beneficial for pharmacologists, molecular biologists, and scientists focused on cancer-research.
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